Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteriaYHDP, TAMB 및 YDBH의 부재는 그람 음성 박테리아에서 글리세로 포스 포스 폴리티드 수송 및 세포 형태의 결함으로 이어진다Research Article Published on 2022-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulate adjust anterograde antibiotic Antibiotic resistance asymmetric Bacterial balance biosynthetic biosynthetic pathways Cell cell envelope cell lysis changes in characterized component contribute Critical Defense effective foundation gram Gram-negative bacteria homeostasis homologues inner leaflet leads lipopolysaccharide LPS maintain maintaining membrane membrane vesicles morphology mutant offer outer membrane overexpression pathway phenotype Phenotypes Protein provide reducing rescued restored sensitivity shedding the cell Therapies Threats translocated Transport understanding vesicles viability [DOI] 10.1371/journal.pgen.1010096 PMC 바로가기 [Article Type] Research Article
A novel type of colistin resistance genes selected from random sequence space무작위 서열 공간에서 선택된 새로운 유형의 콜리스틴 내성 유전자Research Article Published on 2021-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation activity addition analysis antibiotic Antibiotic resistance antibiotic treatments auxiliary Bacteria Cell cell envelope chimeric clinical isolates colistin d e novo de novo de novo gene described determinant determine dissemination DNA DNA sequence DNA sequences domain dominant E . coli Escherichia coli Evolution examined example expand expressed expression generate growth growth defects idea in vivo Interaction isolate kinase kinases limit lipopolysaccharide low expression levels mechanism Modification modifications non-coding DNA non-coding region non-coding regions Open reading frame open reading frames Pathogens peptide peptides provided random Randomly resistance gene resistance genes selected sequence Spread subsequent substrate Support Surveillance the cell transfer transmembrane domain Treatment variant [DOI] 10.1371/journal.pgen.1009227 PMC 바로가기 [Article Type] Research Article
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica포스포릴레이 BarA/SirA는 Salmonella enterica에서 비동족 조절기 RcsB를 활성화합니다.Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated activating addition Alter Bacteria bacterium binding site Cell cell envelope cell wall changes in condition Control detect domain environmental stress expressed Gene Expression Genes growth help Infection life logarithmic growth Luria-Bertani medium modify organism Organisms outer membrane perturbations promote Protein Proteins RcsB regulator Regulatory respond RNA Salmonella Signal transduction specificity Spectrum Stress Transcription [DOI] 10.1371/journal.pgen.1008722 PMC 바로가기 [Article Type] Research Article
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article